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KMID : 1159320220240040453
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Korean Journal of Vision Science
2022 Volume.24 No. 4 p.453 ~ p.459
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Development of Thermo-Responsive Antibiotic-Eluting Contact Lenses Using N-Isopropylacrylamide-Based Nanostructures
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Kim Jong-Lae
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Abstract
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Purpose : We prepared antibiotic-eluting thermo-sensitive nanostructures in order to manufacture smart contact lenses in which the antibiotic is not eluted during storage and the antibiotic is eluted only when worn on the eye.
Methods : Emulsion polymerization was performed to synthesize p(NIPAAm)-based nanostructures, which were introduced into contact lenses through a sandwich method. The antibiotic levofloxacin (LVF) was loaded on the contact lens through the soaking method, and the antibiotic elution was analyzed according to the temperature.
Results : Temperature-sensitive p(NIPAAm)-based nanostructures with a size of 20-40 nm were synthesized through emulsion polymerization using sodium n-dodecyl sulfate (SDS) micelle templates, which were confirmed by TEM and particle size analysis. The nanostructures were introduced into the contact lens through the sandwich method, and the antibiotic was loaded into the nanostructures inside the lens through the soaking method. The release profiles of antibiotics were analyzed at 25 oC and 35 oC, respectively. At room temperature, the antibiotic was released within 3 ug, but at 35 oC most of the antibiotic was released within 2 hours and up to 10 ug was released.
Conclusion : In this study, thermo-sensitive smart antibiotic-eluting contact lenses were manufactured by synthesizing thermo-sensitive nanostructures, applying it to a contact lens, and loading an antibiotic. The thermo-sensitive nanostructures were able to successfully load antibiotics in the contact lens, stored a considerable amount of antibiotics at room temperature, and released a large amount of antibiotics up to 10 μg when the temperature increased. The results of this study are expected to play a significant role in the development and commercialization of smart ophthalmic medical devices and contact lenses for drug delivery.
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KEYWORD
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Antibiotic, Contact Lens, Hydrogel, Thermo-sensitivity
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